Our flagship product targets the deepest layer of the epigenome - DNA methylation.
MeTLAND®
Precision targeting of methylated CpG islands across the genome.
Product: MeTLAND® DNA Methylation Kit v1.1.
Description: Allows for comprehensive whole genome DNA methylation profiling.
Efficiency: Streamlined less than 24h protocol with a total hands-on time of less than 8h.
Input: Optimized for 250,000 cells per sample.
A Streamlined Approach from Nuclei to Library
WORKFLOW
250K cells
Minimum cell input
1x-8x
Scalable reaction volume
<24h Protocol
Total workflow duration
Protocol overview
NGS-Ready
STEP 01
Library ready for sequencing
Nuclei extraction
STEP 02
Complex binding overnight
Capture and
Pre-Amplification
Library Preparation
STEP 03
STEP 04
STEP 05
NGS and Data Analysis
Interested in MeTLAND®?
Try our Early Access Program
FAQs
1. What are the main benefits/advantages of using MeTLAND?
MeTLAND is a fast, user-friendly DNA methylation workflow that fits into any standard molecular biology lab.
It requires no harsh chemicals or specialized equipment and preserves DNA integrity throughout the process.
Key advantages:
> Requires only ~30M reads for high-quality data
> Rapid library preparation with minimal hands-on time
> Enables discovery-driven analysis with high-complexity libraries
2. What are the current offerings at NEXUS Epigenomics?
MeTLAND Early Access Program launched in Q4 2025 for selected researchers to benchmark our chemistry.
3. What types of samples can be used with MeTLAND?
MeTLAND works across a wide range of inputs including cell lines, primary cells, nuclei suspensions, fresh or frozen tissues. We are also optimizing compatibility with FFPE (formalin-fixed, paraffin-embedded) samples.
4. What is the minimum starting material needed for MeTLAND?
Cell suspensions: 200,000 – 250,000 cells.
Tissues: Varies with complexity, rigidity, and density; as a general guide, start with ~100-150 mg.
5. What is the cost?
Please contact us for current pricing.
We offer competitive pricing tailored to project size, sample volume, and workflow needs.